Author(s): Mohammad Abdul Motalib Momin | Sm. Faysal Bellah | Afrina Afrose | Kaniz Fatima Urmi | Kaiser Hamid | Md. Sohel Rana
Journal: Journal of Pharmaceutical Sciences and Research
ISSN 0975-1459
Volume: 4;
Issue: 8;
Start page: 1877;
Date: 2012;
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Keywords: Senna siamea | Phytochemical Screening | Cytotoxicity | Ethanolic extract
ABSTRACT
The present study was carried out to evaluate the phytochemical properties and cytotoxicity potential for ethanolic extract of Senna siamea leaf. Identification of the chemical constituents of plant extract was determined following the standard procedures. In phytochemical screening, the crude extract was tested for the presence of different chemical groups like reducing sugar, tannins, saponins, steroids, flavonoids, gums, alkaloids and glycosides. Cytotoxicity potential was assessed by the brine shrimp lethality bioassay method. Phytochemical screening confirmed the presence of tannins, steroids and glycosides. Incase of cytotoxicity assay, the extract showed moderate cytotoxic activity having LC50 value of 68.633 μg/ml. The present study concludes that the leaf of Senna siamea may be a potential source of cytotoxic compounds. The next step would be to isolate the individual compounds responsible for the observed activity and the probable mechanism of action of it.
Journal: Journal of Pharmaceutical Sciences and Research
ISSN 0975-1459
Volume: 4;
Issue: 8;
Start page: 1877;
Date: 2012;
VIEW PDF
DOWNLOAD PDF Original pageKeywords: Senna siamea | Phytochemical Screening | Cytotoxicity | Ethanolic extract
ABSTRACT
The present study was carried out to evaluate the phytochemical properties and cytotoxicity potential for ethanolic extract of Senna siamea leaf. Identification of the chemical constituents of plant extract was determined following the standard procedures. In phytochemical screening, the crude extract was tested for the presence of different chemical groups like reducing sugar, tannins, saponins, steroids, flavonoids, gums, alkaloids and glycosides. Cytotoxicity potential was assessed by the brine shrimp lethality bioassay method. Phytochemical screening confirmed the presence of tannins, steroids and glycosides. Incase of cytotoxicity assay, the extract showed moderate cytotoxic activity having LC50 value of 68.633 μg/ml. The present study concludes that the leaf of Senna siamea may be a potential source of cytotoxic compounds. The next step would be to isolate the individual compounds responsible for the observed activity and the probable mechanism of action of it.
