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Polymorphism of detoxification genes and predisposition to the development of Parkinson’s disease in Uzbek individuals

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Author(s): Khanifa Khalimova | Malika Raimova | Rustam Matmurodov | Khurshidakhon Rasulova | Amina Burnasheva | Yekaterina Jmirko | Rustam Mukhamedov

Journal: European Medical, Health and Pharmaceutical Journal
ISSN 1804-5804

Volume: 2;
Start page: 38;
Date: 2011;
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Keywords: Parkinskon’s Disease | GSTT1 and GSTM1 Genes.

ABSTRACT
According to our research, Uzbek individuals with Parkinson’s disease have high prevalence of 0/0 polymorphisms of GSTT1 and GSTM1 genes, as well as combinations of GSTT1 (0/0)/GSTM1/(0/0) genotypes. These mutations are associated with an earlier debut of the disease, its mixed form, and rapid rate of progression. Determination of mutationsin GSTT1 and GSTM1 genes of xenobiotic detoxification in patients with Parkinson’s disease confirms multifactorial nature of this pathology and the role of the influence of various external factors in the modification of clinical signs of disease and its prognosis.
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