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Possible mechanism(s) of the relaxant effect of asafoetida (Ferula assa-foetida) oleo-gum-resin extract on guinea-pig tracheal smooth muscle

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Author(s): Zahra Gholamnezhad | Goltaj Byrami | Mohammad Hossein Boskabady | Mehrdad Iranshahi

Journal: Avicenna Journal of Phytomedicine
ISSN 2228-7930

Volume: 2;
Issue: 1;
Start page: 10;
Date: 2011;
Original page

Keywords: Ferula Assafoetida | Aqueous gum extract | Relaxant effects | Guinea pig | Tracheal smooth muscle

ABSTRACT
Objective: Asafoetida (Ferula assa-foetida) is known as a valuable remedy for whooping cough, pneumonia, bronchitis in children and asthma treatment in folk medicine. In the present study the relaxant effects of the asafoetida on tracheal smooth muscle of guinea pigs and its probable mechanism(s) were examined.Materials and Methods: The relaxant effects of three cumulative concentrations of the aqueous extract (2, 5 and 10 mg/ml), theophylline (0.25, 0.5 and 0.75 mM) and saline were examined on non-incubated tracheal smooth muscle of guinea pig precontracted by 10 ┬ÁM methacholine (group 1); preincubated tissues by propranolol and chlorpheniramine, contracted by methacholine (group 2) and preincubated tissues by propranolol, contracted by methacholine (group 3), (n=6 for each group). Results: All concentrations of theophylline in group 1 and all concentrations of the extract in the other three groups showed significant relaxant effects compared to that of saline (p
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