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Post-genomics of the model haloarchaeon Halobacterium sp. NRC-1

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Author(s): DasSarma Shiladitya | Berquist Brian | Coker James | DasSarma Priya | Müller Jochen

Journal: Saline Systems
ISSN 1746-1448

Volume: 2;
Issue: 1;
Start page: 3;
Date: 2006;
Original page

ABSTRACT
Abstract Halobacteriumsp. NRC-1 is an extremely halophilic archaeon that is easily cultured and genetically tractable. Since its genome sequence was completed in 2000, a combination of genetic, transcriptomic, proteomic, and bioinformatic approaches have provided insights into both its extremophilic lifestyle as well as fundamental cellular processes common to all life forms. Here, we review post-genomic research on this archaeon, including investigations of DNA replication and repair systems, phototrophic, anaerobic, and other physiological capabilities, acidity of the proteome for function at high salinity, and role of lateral gene transfer in its evolution.
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