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Potential Chemopreventive Effect Of "Procont" On Mirna Expression In Cba/Ca Mice

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Author(s): MÓNIKA SZIRMAI | KRISZTINA JUHÁSZ | ANDRÁS BERTHA | KATALIN GOMBOS | INGRID MAGDA | PÉTER RÉVÉSZ | ISTVÁN EMBER | Katalin Gőcze

Journal: European Medical, Health and Pharmaceutical Journal
ISSN 1804-5804

Volume: 3;
Start page: 24;
Date: 2012;
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Keywords: Procont | Mirna expression | Chemoprevention

ABSTRACT
Background: There is emerging molecular evidence concerning the modification of miR expression pattern after thetreatment with chemopreventive agents. We investigated whether a potential chemopreventive agent called "Procont"deriving from a biological system has a positive effect on the DMBA induced dysregulation of let7a, miR21 and miR146a miRNAs. Materials and Methods: CBA/CA H2k inbred mice were fed by Procont for 7 days before the intraperitonealinjection of DMBA. After one week of the beginning of Procont diet we analized the let7a, miR21, miR146agene expression in vital organs of mice. Results: The Procont feeding significantly decreased all of the investigated miRNAexpression compared with either the mice on a normal diet in the control group or mice were exposed to DMBA alone.Conclusion: The results indicate that "Procont" diet has a potential chemopreventive effect in mice exposed to DMBA.
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