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The practical implications of using estimated GFR as the presumed reference variable to estimate transplant chronic kidney disease

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Author(s): Hamdi Elmoselhi | Mohammad Akhtar Hossain | Said Khamis | Rahul Mainra | Abubaker Hassan | Ahmed Shoker

Journal: Nephrology Reviews
ISSN 2035-8261

Volume: 3;
Issue: 1;
Start page: e2;
Date: 2011;
Original page

ABSTRACT
We determined the proportions of matched kidney transplant isotope GFRs (iGFRs) to the estimated functions (eGFRs) calculated from Isotope Dilution Mass Spectrometry (IDMS), Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI), and Cockcroft-Gault (CG) equations. Method: 1403 iGFR/eGFR pairs on 390 kidney transplant patients were compared considering the iGFR or eGFR as the reference or test variable. Results: Conformity of iGFR to CG estimates demonstrated the least bias of 1.3±18.4 mL/ min/1.73 m2 (compared to 1.5±19.4 and -2.2±19.2 for IDMS and CKDI-EPI, P
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