Author(s): Goyal Manu | Mohammad Noorjahan | Palanki Satya | Vaniawala Salil
Journal: Indian Journal of Medical and Paediatric Oncology
ISSN 0971-5851
Volume: 31;
Issue: 3;
Start page: 142;
Date: 2010;
Original page
Keywords: Flow cytometry | fluorescent in-situ hybridization | free light chains | primary plasma cell leukemia | transplant
ABSTRACT
Primary plasma cell leukemia is a rare form of plasma cell dyscrasia. We present a case which had leukocytosis with numerous circulating plasma cells in the peripheral blood. Flow cytometry revealed an unusual CD117 expression. Free light chain analysis in the serum showed a markedly elevated level of free lambda light chains. Radiography did not reveal any lytic lesions. Fluorescent in-situ hybridization analysis revealed deletion of 13q14.3 and t(4;14)/t(11;14), while the cytogenetic analysis was normal. The patient was given chemotherapy and was subjected to autologous stem cell transplant, after which she is in complete remission till date.
Journal: Indian Journal of Medical and Paediatric Oncology
ISSN 0971-5851
Volume: 31;
Issue: 3;
Start page: 142;
Date: 2010;
Original page
Keywords: Flow cytometry | fluorescent in-situ hybridization | free light chains | primary plasma cell leukemia | transplant
ABSTRACT
Primary plasma cell leukemia is a rare form of plasma cell dyscrasia. We present a case which had leukocytosis with numerous circulating plasma cells in the peripheral blood. Flow cytometry revealed an unusual CD117 expression. Free light chain analysis in the serum showed a markedly elevated level of free lambda light chains. Radiography did not reveal any lytic lesions. Fluorescent in-situ hybridization analysis revealed deletion of 13q14.3 and t(4;14)/t(11;14), while the cytogenetic analysis was normal. The patient was given chemotherapy and was subjected to autologous stem cell transplant, after which she is in complete remission till date.
