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Primary plasma cell leukemia with light chain secretion and multiple chromosomal abnormalities: How successfully treated? - A case report with review of literature

Author(s): Goyal Manu | Mohammad Noorjahan | Palanki Satya | Vaniawala Salil

Journal: Indian Journal of Medical and Paediatric Oncology
ISSN 0971-5851

Volume: 31;
Issue: 3;
Start page: 142;
Date: 2010;
Original page

Keywords: Flow cytometry | fluorescent in-situ hybridization | free light chains | primary plasma cell leukemia | transplant

Primary plasma cell leukemia is a rare form of plasma cell dyscrasia. We present a case which had leukocytosis with numerous circulating plasma cells in the peripheral blood. Flow cytometry revealed an unusual CD117 expression. Free light chain analysis in the serum showed a markedly elevated level of free lambda light chains. Radiography did not reveal any lytic lesions. Fluorescent in-situ hybridization analysis revealed deletion of 13q14.3 and t(4;14)/t(11;14), while the cytogenetic analysis was normal. The patient was given chemotherapy and was subjected to autologous stem cell transplant, after which she is in complete remission till date.

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