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Prognostic Role of a Soluble Fas in Patients with a Mammary Gland Cancer

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Author(s): A.S. Ozhereliev | D.V. Komov | S.G. Abbasova | M.B. Orinovsky | I.V. Kolyadina | L.K. Ovtchinnickova | A.A. Tuleuova | M.V. Grishkevich | U.R. Mamedov | Z.K. Karabeckova | I.K. Vorotnickov

Journal: Sovremennye Tehnologii v Medicine
ISSN 2076-4243

Issue: 4;
Start page: 37;
Date: 2010;
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Keywords: Mammary gland cancer | Stages T1—2N0M0 | sFas | Prognosis

ABSTRACT
The results of a comparative study of the soluble Fas (sFas) levels in a blood serum of the healthy females (n=55) and patients with a mammary gland cancer (MGC) in a stage of T1N0M0 (n=76) and T2N0M0 (n=172), the connections of sFas with the basic clinicomorphologic factors and a disease prognosis are presented. The sFas is revealed with a similar rate in a blood serum and patients with a mammary gland cancer both in a stage of T1N0M0 (53.9%) and in a stage of T2N0M0 (59.3%), and in healthy females (48.1%), however its levels were trustworthy lower than in healthy ones (0.73±0.10 ng/ml) compared to a general group of patients (0.97±0.10 ng/ml). Besides, the sFas initial value connection with an age and reproductive function of patients, with a disease stage and a tumor receptor status is not established, but a tight connection with a degree of the mammary gland cancer malignancy is found. A possible connection of sFas with a prognosis of the mammary gland cancer patient survival rate without recurrence at a stage T2N0M0 is discussed.

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