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Prolonged febrile illness due to CTX-M-15 extendedspectrum β-lactamase-producing Klebsiella pneumoniae infection in Nigeria

Author(s): Oladipo A. Aboderin | Olufemi Adefehinti | Babatunde W. Odetoyin | Amadin A. Olotu | Iruka N. Okeke | Olugbenga Adeodu

Journal: African Journal of Laboratory Medicine
ISSN 2225-2002

Volume: 1;
Issue: 1;
Date: 2011;
Original page

Keywords: septicaemia | CTX-M-15 | Klebsiella pneumoniae | Nigeria

We report on an 8-year-old patient with septicaemia unresponsive to therapy for five weeks. Undetected, extended-spectrum β-lactamase (ESBL) production by the infecting Klebsiella strain was regarded as responsible for treatment failure. Intravenously administered imipenem during the sixth week led to sustained resolution of fever. Resource-limited hospitals can incur prohibitive costs from ESBL-producer infections because of diagnostic limitations and consequent treatment failure involving prolonged supportive therapy.
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