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Prospects of engineering metabolites in microorganisms for therapeutics

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Author(s): Muthukumar, M., Shubhendu Seal, Nimisha Sharma, Kulbhushan, Navin Srivastava and M. Rabeeth

Journal: GERF Bulletin of Biosciences
ISSN 2229-6433

Volume: 2;
Issue: 1;
Start page: 49;
Date: 2011;
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Keywords: metabolic engineering | therapeutics | microbes

ABSTRACT
Engineering metabolites in microorganisms are new tools for production of therapeutics. Microbial metabolic engineering involving manipulation of metabolic fluxes has helped in the production of novel antibiotics. The process of metabolic engineering and strategies adopted for over production of antibiotics, enzymes of therapeutical value and other therapeutic compounds are briefly described here. Bacteria, fungi and yeasts have been engineered for metabolites which are discussed with examples in this review.
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