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Protective Effect of Ocimum sanctum on Disposition Kinetics of Sulphadimidine in Lead-Treated Cockerel

Author(s): A. Prakash | S. P. Singh | R. Varma | G. K. Choudhary | R. Sajan

Journal: Iranian Journal of Pharmacology and Therapeutics
ISSN 1735-2657

Volume: 9;
Issue: 1;
Start page: 1;
Date: 2010;
Original page

Keywords: Disposition Kinetics | Sulphadimidine | Lead | Cockerels | Oscimum Sanctum

This study was carried out to evaluate the protective effect of Ocimum sanctum (tulsi) on lead-induced alteration in disposition kinetics of sulphadimidine (SD) in cockerels. Twenty-one, four-week male white leghorn (WLH) chicks were randomly divided into groups I, II and III (7 in each) and were fed at dietary with 0 ppm lead and no tulsi (group I, Control), 100 ppm lead (group II), or 100 ppm lead + 100 ppm tulsi (group III). After four weeks, disposition kinetics of intravenous single dose administration of SD (50 mg /kg) was determined in each bird. The mean values of elimination half-life, distribution–half, AUC, and volume of distribution were significantly (p
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