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Qualitative and Quantitative Estimation of Water Insoluble Drugs from its Formulations Simultaneously: a Hydrotropic Approach

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Author(s): Rajesh Sharma | Geetam Pathodiya | Ganesh Prasad Mishra

Journal: Stamford Journal of Pharmaceutical Sciences
ISSN 1999-7108

Volume: 3;
Issue: 2;
Start page: 37;
Date: 2010;
Original page

Keywords: Derivative spectrophotometry method | area under curve method | multi-component method | ciprofloxacin hydrochloride | tinidazole | hydrotropic agent

ABSTRACT
Three accurate, precise, sensitive and economical procedures for simultaneous determination of ciprofloxacin hydrochloride and tinidazole in tablet dosage form have been developed. In the present investigation, 1.0M urea solution (hydrotropic solubilising agent) was employed to solubilise, ciprofloxacin, a poorly water-soluble drug, from fine powder of its tablets to carryout spectrophotometric analysis. The methods employed were derivative spectrophotometry method, area under curve method and multi-component method. The result showed that Beer's-Lambert's law was obeyed in concentration range of 5-50 μg/ml with good linearity, with a R2 value >0.99, for both the drugs in all the methods. The recoveries were within 99.42 -101.27% for ciprofloxacin hydrochloride and 99.61-101.81% for tinidazole. Precision was good with acceptable limits of detection (LOD) and quantitation (LOQ) for both compounds. The optimized methods showed good reproducibility and recovery with standard deviation of
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