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Quantification of plasma fibrinogen degradation products in oral submucous fibrosis: A clinicopathologic study

Author(s): Koshti Supriya | Barpande Suresh

Journal: Journal of Oral and Maxillofacial Pathology
ISSN 0973-029X

Volume: 11;
Issue: 2;
Start page: 48;
Date: 2007;
Original page

Keywords: Fibrinogen degradation products | fibrin

Oral submucous fibrosis (OSMF) has a multifactorial etiology. Recent investigations have shown the role of fibrinogen degradation products (FDP) in the causation of OSMF. A study of 35 cases showed a significant linear increase of plasma FDP levels with an increase in the clinical grade. Comparison with the histological grade of OSMF showed an increase in plasma FDP levels with increase in histological grade of OSMF, but was not statistically significant. Plasma FDP is reported to be an early indicator of fibrin deposition. When the plasma FDP increases, the fibrin deposited also increases. This strengthens the finding that OSMF is primarily a change of connective tissue causing excessive deposition of fibrin. This in turn leads to restriction of mouth opening.

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RPA Switzerland

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