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The Reaction of Cyanoacetylhdrazine with Furan-2-Aldehyde: Novel Synthesis of Thiophene, Azole, Azine and Coumarin Derivatives and Their Antitumor Evaluation

Author(s): Wagnat W. Wardakhan | Sherif M. Sherif | Rafat M. Mohareb | Amr S. Abouzied

Journal: International Journal of Organic Chemistry
ISSN 2161-4687

Volume: 02;
Issue: 04;
Start page: 321;
Date: 2012;
Original page

Keywords: Acetylhydrazine | Hydrazide-Hydrazone | Thiophene | Thiazole | Pyridine | Coumarin | Antitumor

The reaction of cyanoacetylhydrazine 1 with furan-2-aldehyde 2 gives the hydrazide-hydrazone derivative 3. The latter compound undergoes a series of heterocyclization reactions to give new heterocyclic compounds. The antitumor evaluation of the newly synthesized products against three cancer cell lines, namely breast adenocarcinoma (MCF-7), non-small cell lung cancer (NCI-H460) and CNS cancer (SF-268) were recorded. Some of the synthesized compounds show high inhibitory effects.
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