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Reduced infarct size in neuroglobin-null mice after experimental stroke in vivo

Author(s): Raida Zindy | Hundahl Christian | Kelsen Jesper | Nyengaard Jens | Hay-Schmidt Anders

Journal: Experimental & Translational Stroke Medicine
ISSN 2040-7378

Volume: 4;
Issue: 1;
Start page: 15;
Date: 2012;
Original page

Keywords: Neuroglobin | Knock out | Ischemia | Immunohistochemistry | Brain

Abstract Background Neuroglobin is considered to be a novel important pharmacological target in combating stroke and neurodegenerative disorders, although the mechanism by which this protection is accomplished remains an enigma. We hypothesized that if neuroglobin is directly involved in neuroprotection, then permanent cerebral ischemia would lead to larger infarct volumes in neuroglobin-null mice than in wild-type mice. Methods Using neuroglobin-null mice, we estimated the infarct volume 24 hours after permanent middle cerebral artery occlusion using Cavalieri’s Principle, and compared the infarct volume in neuroglobin-null and wild-type mice. Neuroglobin antibody staining was used to examine neuroglobin expression in the infarct area of wild-type mice. Results Infarct volumes 24 hours after permanent middle cerebral artery occlusion were significantly smaller in neuroglobin-null mice than in wild-types (p 
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