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The Relation between Serum Level of Hs-CRP (High Sensitivity CReactive Protein) with the Result of Coronary Vessels Angiography in the Patients with Positive Exercise Treadmill Testing

Author(s): Mohammad Mahdi Parvizi | Zhila Dorfeshan

Journal: Scientific Medical Journal
ISSN 1026-8960

Volume: 11;
Issue: 5;
Start page: 499;
Date: 2012;
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Keywords: hs-CRP | coronary angiography | positive exercise treadmill test | atherosclerosis.

Background and Objective: Experimental and clinical evidence have established inflammatory processes as important contributors to atherosclerosis as well as to the vulnerability of an atherosclerotic lesion to rupture. The purpose of this study was to assess the relationship between plasma level of hs-CRP as noninvasive evidence of inflammation and its screening efficacy in diagnosis of atherosclerosis and extent of coronary vessels stenosis. Subjects and Methods: Our 87 cases selected from all patients who came with chief complaint of chest pain and had positive exercise treadmill test in paraclinic examination, and were referred for coronary angiography. Serum hs-CRP level of all these patient was cheked. Patients with cardiac dysfunction, rheumatic disease and infective disease were excluded from our study. The Patients were divided into two groups according to angiography results: group 1 comprised of 47 patients (24 men vs 23 women) with normal coronary angiography and group 2 comprised of 40 patients (28 men vs 12) with abnormal coronary angiography. The statistical analysis was performed with SPSS version 15. Results: there was statistically a significant difference between age, sex and positive history of diabetic mellitus between two groups (p< 0.05). Hs-CRP level was similar in both groups. There was no statistically significant correlation between HsCRP level and coronary angiography results. Conclusion: In this study, we found that there is not a clear relationship between plasma level of high sensitivity CRP with exercise induced ischemia, and also extent or the presence of coronary atherosclerosis.
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