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Respiratory syncytial virus outbreak in neonatal intensive care unit: Impact of infection control measures plus palivizumab use

Author(s): Silva Camila de A | Dias Lívio | Baltieri Sandra R | Rodrigues Tatiane T | Takagi Neusa | Richtmann Rosana

Journal: Antimicrobial Resistance and Infection Control
ISSN 2047-2994

Volume: 1;
Issue: 1;
Start page: 16;
Date: 2012;
Original page

Keywords: Respiratory syncytial virus | Outbreak | Palivizumab | Neonatal intensive care

Abstract Background The occurrence of a respiratory syncytial virus (RSV) outbreak in a Neonatal Intensive Care Unit (NICU) is related to unfavorable outcomes, as this infection can lead to respiratory distress and death in premature in infants. Report the successful control of an outbreak that occurred in April 2010 in a NICU. Methods After the index case, of 18 premature infants placed in the same room 10 infants were infected. Of those 10, 6 developed mild to moderate respiratory symptoms, 4 persisted asymptomatic and no death occurred. Contact and respiratory precautions were rapidly initiated, the infants were cohorted in 3 different rooms and palivizumab was administered to all contacts. Results The outbreak was controlled and no new cases were subsequently indentified. Conclusion Standard infection control measures plus palivizumab prophylaxis were efficient in rapid control of the outbreak.
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