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REVIEW ARTICLE – Intravenous paracetamol in pediatrics: A global perspective

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Author(s): Muzammil Irshad, MBBS | Mehjabeen Malik, MBBS | Aamir Furqan, MBBS

Journal: Anaesthesia, Pain & Intensive Care
ISSN 1607-8322

Volume: 16;
Issue: 3;
Start page: 311;
Date: 2012;
Original page

Keywords: Acetaminophen | Paracetamol | Propacetamol | Cyclooxygenase-2 inhibitors

ABSTRACT
Intravenous (IV) Paracetamol is an excellent post operative analgesic and antipyretic in children. Efficacy and tolerability of IV Propacetamol have been established in pediatric practice. It is believed that paracetamol works by inhibiting cyclooxygenase-2 (COX-2) enzymes. Studies bring to light that therapeutic doses of IV acetaminophen are effective and tolerable in children with least chances of hepatotoxicity. However, overdose toxicity has been reported in children and drug induced hypotension in febrile critically ill patients. Therapeutic doses according to body weight of neonates and children can be administered in hospital settings. Special education of health care staff regarding precise dose and solution is necessary to assess the role of IV paracetamol preparation in pediatric practice.
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