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A Review on Liquid Solid Compacts

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Author(s): V.N.L. Sirisha | B. Sruthi | M. Namrata | I. Bhavani Harika | P.Kirankumar | Y. Kiran Kumar Rao | K. Pranavi | S. Sindhura | N.Vamsi Krishna | O. Uma Maheshwar Rao

Journal: International Journal of Pharmaceutical and Phytopharmacological Research
ISSN 2250-1029

Volume: 2;
Issue: 2;
Start page: 116;
Date: 2012;
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Keywords: Liquid solid compact | Liquid medications | Non-volatile Vehicles | Dissolution rate.

ABSTRACT
At present 40% of the drugs in the development pipelines, and approximately 60% of the drugs coming directly from synthesis are poorly soluble. The limited solubility of drugs is a challenging issue for industry, during the development of the ideal solid dosage form unit. Liqui-solid compacts technique is a new and promising approach to overcome this consequence and that can change the dissolution rate of water insoluble drugs and increase the bioavailability of the drugs. According to the new formulation method of liqui-solid compacts, liquid medications such as solutions or suspensions of water insoluble drugs in suitable nonvolatile liquid vehicles can be converted into acceptably flowing and compressible powders by blending with selected powder excipients. It has been speculated that such systems exhibit enhanced release profiles. In this case, even though the drug is in a solid dosage form, it is held within the powder substratin solution or, in a solubilized, almost molecularly dispersed state, which contributes to the enhanced drug dissolution properties.
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