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Role of ADA in immunological disorders - Diabetes mellitus and Thyroid dysfunction

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Author(s): Vishnu Madhuri | V. Sampath Kumar | Shruti Mohanty

Journal: MRIMS : Journal of Health Sciences
ISSN 2321-7006

Volume: 1;
Issue: 1;
Start page: 17;
Date: 2013;
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Keywords: Adenosine deaminase | Diabetes mellitus | Hyperthyroidism | Hypothyroidism

ABSTRACT
Background: Adenosine deaminase (ADA) is a cytosolic enzyme, which participates in development and maintenance of the immune system. Diabetic patients have a higher prevalence of thyroid disorders compared to the normal population because patients with one organ-specific autoimmune disease are at risk of developing other autoimmune disorders. Methods: A total number of one hundred subjects were divided into four groups consist of group A. Type II Diabetic patients, group B. Hypothyroid patients, group C. Hyperthyroid patients and group D. Healthy controls of either sex between age group of 30-70 years. The following biochemical parameters were estimated for all the groups. Fasting plasma glucose, Serum T3, T4, TSH and Adenosine deaminase. Results: Mean serum ADA levels were raised in diabetic and hypothyroid patients when compared to that in controls and which was statistically significant (p
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