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The role of antigens and HLA class I haplotypes in indigenous women in Tashkent with hysteromyoma

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Author(s): Landish Isanbaeva

Journal: Medical and Health Science Journal
ISSN 1804-1884

Volume: 7;
Issue: 3;
Start page: 39;
Date: 2011;
Original page

Keywords: Hysteromyoma | tumors | HLA-system antigens and haplotypes.

ABSTRACT
Immunogenetic analysis on HLA I class in 177 indigenous women with uterine myoma showed the positive association in the risk of uterine fibroids with antigens HLA-B8/B22 and haplotype A28/B22; antigens HLA-A28, Cw5 and haplotype B17-Sw5 played role of auxiliary markers. HLA-antigens A2, B35, Cw4 and haplotypes A2-B35, B5-Cw4 showed the negative association. Carrying immunogenetic studies may be useful to search for individual genes involved in the determination of the disease - uterine fibroids, especially among patients with hereditary anamnesis.

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