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The Role of IL-18, CCL5 and their receptors as Diagnostic Markers in Breast Cancer

Author(s): Razan Ahmed Fakieh, Safa Taha and Moiz Bakhiet

Journal: GERF Bulletin of Biosciences
ISSN 2229-6433

Volume: 3;
Issue: 2;
Start page: 1;
Date: 2012;
Original page

Keywords: Cytokine | chemokine | interleukin | receptor

Interleukin-18 (IL-18) is a pro-inflammatory cytokine that has been suggested to be a prognostic factor in some cancer types. Also, CCL5 has been considered as a potential contributor to breast cancer progression. Using RT-PCR, this work examined the levels of IL-18, CCL5 and their receptors in patients with breast cancer (BCa) in Bahrain. In this study we compared tissues with and without metastasis to tissues from benign and normal breast. Formalin-fixed paraffin embedded breast tissues were obtained from 25 patients without metastasis, 20 patients with metastasis, 15 with benign tumor and 15 with normal breast tissues (total=75). IL-18/IL-18R expression in metastatic and non-metastatic group was significantly high when compared to control group (p
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