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The role of stem cells in the improvement of brain injuries after hypoxic ischemia

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Author(s): Mohammad Reza Nikravesh | Mehdi Jalali | Hossein Ali Ghafaripoor | Javad Sanchooli | Darioush Hamidi | Shabnam Mohammadi | Masoomeh Seghatoleslam

Journal: Electronic Physician
ISSN 2008-5842

Volume: 4;
Issue: 3;
Start page: 536;
Date: 2012;
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Keywords: Stem cell | Ischemic hypoxia | Frontal cortex

ABSTRACT
Introduction: Nowadays, the important role of stem cells in treatment of many diseases such as stoke is wellknown. Stem cells derived from either bone marrow or cord bloods are good sources for tissues replacement afterpost embryonic injuries.Methods: Fourteen-day-old Wistar rats were used in this study. Rats were subjected to internal carotid arteryocclusion for 30 minutes. Then, animals were received intravenously 2×105 Bromo Deoxy Uridine (BRDU)labeled- cord blood stem cells (CBSCs). Rats with hypoxic conditions that were not received any injection wereassumed as a sham group. Intact animals who did not receive any injection or surgeries were used as a controlgroup.Results: Our results were evaluated according to behavioral tests and immunohistochemistry of the brain especiallyfrontal cortex of the control, sham and experimental groups. Behavioral recovery was observed in the experimentalgroup compared to the either the sham or the control group. In addition, histological studies demonstrated areduction in ischemic cells in the experimental group compared to the sham group.Conclusion: Intravenous transplantation can be a future line in treatment of infants with hypoxic who are exposed toirreversible damages.
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