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Serum uric acid and diabetic nephropathy

Author(s): Momeni Ali

Journal: Journal of Renal Injury Prevention
ISSN 2345-2781

Volume: 1;
Issue: 1;
Start page: 37;
Date: 2012;
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Keywords: Diabetic nephropathy | Uric acid | End-stage renal disease

Implication for health policy/practice/research/medical education:Diabetic nephropathy is the most common cause of end-stage renal disease worldwide. Recently, some prospective randomized controlled trials suggested that lowering of uric acid with allopurinol could decrease the severity of proteinuria and probably slow the progression of renal failure in diabetic patients. Mechanism of beneficial effect of xanthine oxidase inhibitor may related to preventing uric acid-induced renal inflammation.

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