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In silico Identification of Putative Drug Targets in Neisseria meningitidis through Metabolic Pathway Analysis

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Author(s): Shobana K | Thiagarajan B

Journal: Scholars' Research Journal
ISSN 0976-8459

Volume: 1;
Issue: 1;
Start page: 13;
Date: 2010;
Original page

Keywords: Neisseria meningitidis | Putative Drug Targets | Drug Discovery

ABSTRACT
Novel drug targets are required in order to design new defenses against antibiotic-resistant pathogens. In the present study, the Putative Drug Targets in Neisseria meningitidis were identified using in silico methods, through Metabolic Pathway Analysis. Prediction and inference of biological functions from genomic sequences by making use of the pathway data is a new computational approach. Metabolic pathway is important for the survival of all organism. Neisseria meningitidis is a leading cause of infectious childhood mortality worldwide. It is one of the bacterial pathogen which is responsible for Septicemia and Meningitis. In the present study, Pathways of Pathogens Z2491, FAM18, MC58 were compared with human. Benzoate degradation via hydroxylation, D Alanine metabolism, Polyketide sugar unit biosynthesis, Two component system, Phosphotransferase system(PTS) and Type II secretion system are found to be specific pathways which are not present in Human. Genes Involved In Specific Pathway of Neisseria Meningitidis, which are non-homologous to human genome was also studied. Using the Kyoto Encyclopaedia of Genes and Genomes (KEGG) pathways database, revealed some enzymes of Neisseria meningitidis that may be used as drug targets, as they are not present in humans. These can be used as a platform for further investigation to develop effective drugs against Neisseria Meningitidis.
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