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Sinonasal melanoma: Clinical features and diagnostic dilemma

Author(s): Charusheela R.Gore | Pradhan M.Pagaro | N.K.Panicker | Saurav Singh | Shirish S.Chandanwale | Sunita Bamanikar

Journal: International Journal of Pharmacy and Biomedical Sciences
ISSN 0976-5263

Volume: 04;
Issue: 01;
Start page: 21;
Date: 2013;
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Keywords: Sinonasal | Melanoma | Treatment | Amelanotic

Melanoma is malignant tumor of the melanocytes. The great preponderance of melanomas arise in the skin. The other sites of origin include oral and anogenital mucosal surfaces, esophagus, meninges, eyes etc. Primary melanoma of nasal cavities is a rare clinical entity. Its pathogenesis is dueto the neoplastic development of melanocytes of neuroectodermal origin which are located in the nasal mucosa .The patient usually presents with non-specific signs and symptoms such as nasal obstruction and recurrent epistaxis making the diagnosis difficult. It is an aggressive tumor with high incidence of local recurrence and distant metastasis. Inspite of new therapeutic approaches the prognosis is poor. We encountered two cases where there was no clinical suspicion and histopathology caused a diagnostic dilemma, ultimately resolved with immunohistochemistry and electromicroscopy.
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