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Author(s): Dr.Anil Batta

Journal: International Journal of Chemical Sciences and Research
ISSN 2249-0329

Volume: 01;
Issue: 05;
Start page: 39;
Date: 2011;
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Keywords: Keywords: Smokers | Uric acid | CVD | Uric acid | xanthine oxidase | cholesterol and HDL--C.

Smoking has become a usual routine particularly in the youth that has made it a cause of concern. It is a monsterwhich is going to engulf the entire mankind irrespective of the place and sex as this has crossed the sex limits also asthe effect on pregnancies can be devastating. Smoking has become the worst method of committing suicide and homicide as the second hand persons have to be beware of consequences for just having a smoker friend. Keepingall the hazards in mind we tried to find the correlation of smoking in the Subjects enrolled in study by dividing it into two groups; nonsmokers and smokers, each with 60 male volunteers of the same social class and dietary habit without history of alcohol consumption, diabetes mellitus, hyperuricemia and gout, renal, joint, lung or heart diseases. Fasting blood and random urine samples were obtained from both groups for measurement of uric acid and creatinine. Calculation of all three parameters in mind viz.Serum uric acid, total cholesterol, HDL--cholesterol a significant correlation was tried to evaluate between all four parameters. The results were statistically evaluated by standard statistical methods. Studies have shown that a high serum uric acid concentration is a risk factor for coronary artery disease with increased levels of serum cholesterol and d+ecreased levels of HDL cholesterol. However, the issue of whether it is an independent cardiovascular risk factor or simply a marker of co-existing conditions is a matter of controversy. Serum cholesterol in CAD patients was significantly higher than in healthy individuals (7.4 ± 3.7 mg% and 4.4 ±1.2 mg%, respectively, p < 0.01) and remained significantly higher after adjusting for confounding factors (F = 69.45, p< 0.01). An unadjusted odds ratio (OR) of 5.0 was obtained in both genders (p < 0.01). Female patients with > 43% stenosis (clinically significant CAD), regardless of the number of diseased vessels, had higher uric acid concentrations than those with < 43% stenosis even after adjusting for confounders (F = 3.79, p = 0.01). In conclusion, we have demonstrated that high serum uric acid is independently associated with CAD and that uric acid determination could be useful as one of the markers of clinically significant CAD.
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