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Sodium pertechnetate (Na99mTcO4) biodistribution in mice exposed to cigarette smoke

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Author(s): Valenca Samuel | Lima Elaine | Dire Gláucio | Bernardo-Filho Mário | Porto Luís

Journal: BMC Nuclear Medicine
ISSN 1471-2385

Volume: 5;
Issue: 1;
Start page: 1;
Date: 2005;
Original page

ABSTRACT
Abstract Background The biological effects of cigarette smoke are not fully known. To improve our understanding of the action of various chemical agents, we investigated the biodistribution of sodium pertechnetate (Na99mTcO4) in mice exposed to cigarette smoke. Methods Fifteen BALB/c male mice were exposed to the smoke of nine whole commercial cigarettes per day, 3 times/day, for up to 10 days to whole body exposure in a chamber. A control group of 5 BALB/c male mice was sham-smoked. One day later, the exposed and control groups of mice received (7.4 MBq/0.3 ml) of Na99mTcO4 before being killed at 30 min. Bones, brain, heart, intestine, kidney, liver, lungs, muscle, pancreas, spleen, stomach, testis and thyroid were weighed and these organs and blood radioactivity recorded with a gamma counter. The percentage per gram of tissue of injected dose (%ID/g) was determined for each organ. Results Cigarette smoke significantly decreased (p < 0.05) the %ID/g in red blood cells, bone, kidney, lung, spleen, stomach, testis and thyroid of the exposed mice. Conclusion The toxic effects of cigarette smoke reduced the Na99mTcO4 biodistribution.
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