Author(s): Hamzeh Kiyani*, Fatemeh Ghorbani
Journal: Heterocyclic Letters
ISSN 2231-3087
Volume: 3;
Issue: 3;
Start page: 359;
Date: 2013;
Original page
Keywords: Sodium saccharin | isoxazol-5(4H)-ones | three-component reaction
ABSTRACT
As a result of one-pot three-component reaction of ethyl acetoacetate with hydroxylamine hydrochloride and various aromatic aldehydes using sodium saccharin as a catalyst in water, a green and environmentally benign solvent, 4-arylidene-3-methylisoxazol-5(4H)-ones were obtained in high yields. The advantage of this method is efficient, clean, easy work-up, high yields, and shorter reaction time.
Journal: Heterocyclic Letters
ISSN 2231-3087
Volume: 3;
Issue: 3;
Start page: 359;
Date: 2013;
Original page
Keywords: Sodium saccharin | isoxazol-5(4H)-ones | three-component reaction
ABSTRACT
As a result of one-pot three-component reaction of ethyl acetoacetate with hydroxylamine hydrochloride and various aromatic aldehydes using sodium saccharin as a catalyst in water, a green and environmentally benign solvent, 4-arylidene-3-methylisoxazol-5(4H)-ones were obtained in high yields. The advantage of this method is efficient, clean, easy work-up, high yields, and shorter reaction time.
