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Spectrum of hemoglobin variants in Eastern Indian population; a study of 14,145 cases

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Author(s): Suprio Ray Chaudhury | Himansu Roy | Nirmal Kumar Bhattacharyya | Palash Kumar Mondal | Pranab Kumar Biswas | Sumit Roy

Journal: Al Ameen Journal of Medical Sciences
ISSN 0974-1143

Volume: 06;
Issue: 03;
Start page: 243;
Date: 2013;
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Keywords: HPLC | Hemoglobinopathy | Thalassemia

ABSTRACT
Background: Inherited disorders of hemoglobin are extremely common in Indian population ranging from near structurally normal hemoglobins to severe transfusion dependant hemoglobinopathies. Their detection is important epidemiologically and to prevent other more serious hemoglobinopathies in future generations. Objectives: This is a retrospective study, where our objectives are to analyze the different hemoglobin (Hb) variants in West Bengal (WB) population and adjacent areas and to find out which particular district is at risk to which particular hemoglobinopathy. Materials & Methods: The study was done by BIORAD VARIANT using beta thalassemia (thal) short programme using high performance liquid chromatography (HPLC) technique. Complete hemogram of all the surgical and other patients were available before HPLC study. Cases were referred mostly by surgeons and clinicians either after getting abnormal hemogram or for premarital counseling. Results: Out of 14,145 cases 74.35% (10,518 cases) showed normal Hb pattern on HPLC and rest 26.65% (3627 cases) showed some abnormality. Common hemoglobinopathies included beta thal trait, E trait, E beta thal, persistent fetal Hb, thal major, thal minor, HbS trait. Other disorders were rare (
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