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Spinal Substance P and CGRP staining in vincristine, cisplatin, streptozocin or constriction injury-induced neuropathies

Author(s): Coudoré-Civiale.M.A | Ling.B | Balayssac

Journal: Journal of Pharmaceutical Sciences and Research
ISSN 0975-1459

Volume: 2;
Issue: 9;
Start page: 590;
Date: 2010;
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Keywords: cisplatin | vincristine | sciatic nerve | diabetic rat | spinal cord

Substance P and CGRP-expressing neurons were quantified in dorsal horn of rats suffering from painful neuropathy after toxic-, metabolic- or chirurgically-induced injury. The CGRP immunoreactivities wereincreased in both models and the highest values were in diabetic and vincristine-induced rats. Immunostaining showed increase in SP immunoreactivity in diabetic rats. This study shows injury type-specific SP and CGRP liberation according to the etiology and delay after induction.

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