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STUDY OF INTERACTION OF DRUGS WITH BODY-ALIKE MACROMOLECULE (POLYVINYLPYRROLIDONE) BY ULTRA VIOLET SPECTROSCOPIC METHOD

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Author(s): AKHTAR SAEED | AMIN UR RAHMAN | NAZAR UL ISLAM | MOHAMMAD SAEED | S. M. ASHHAD HALIMI

Journal: Malaysian Journal of Pharmaceutical Sciences
ISSN 1675-7319

Volume: 4;
Issue: 2;
Start page: 63;
Date: 2006;
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Keywords: Polyvinylpyrrolidone | Phenol | Benzoic acid | Acetyl salicylic acid | UV-visible spectrometry

ABSTRACT
UV-visible spectrophotometric technique was used to study the interaction of polyvinylpyrrolidone (PVP) with co-solutes: phenol, benzoic acid, sodium benzoate, salicylic acid and acetyl salicylic acid in aqueous medium. Changes in the absorption spectra of the co-solutes were observed in the presence of PVP from 200 to 210 nm. The changes were attributed to interaction of PVP molecules with the co-solute molecules. As the concentration of the co-solute increased, a red shift in the bands was observed indicating an increase in interaction between PVP and the co-solute.
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