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Study of Prevalence of Non - Polio Enteroviruses in Children of 0-15 Years of Raichur District

Author(s): Venkatesh Patil | Rajeshawri R Surpur | Anitha.M.R | V ijayanath.V

Journal: Journal of Pharmaceutical and Bioanalytical Science
ISSN 2278-828X

Volume: 2;
Issue: 1;
Start page: 1;
Date: 2013;
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Keywords: Prevale nce | Acute flaccid paralysis(AFP) | Non - polio enteroviruses (NPEV)

Background:Enteroviruses are among the most common viruses infecting humans worldwide and theyareassociated with diverse clinical syndromes. Acute flaccid paralysis (AFP) is a clinicalmanifestation of enteroviral neuropathy, transverse myelitis, Gullian-Barre syndrome, traumaticneuritis and many other nervous system disorders. The objective of this study was to understand therole of Non-polio enteroviruses (NPEV) towards the crippling disorders.Objectives of the Study:To know the prevalence of NPEV in stool sample collected from resident AFPcases in the age group of 0-15 years in Raichur district and to know the prevalence of residualweakness in resident AFP cases in childrenage 0-15 years of Raichur district.Method:All cases of AFP reported by different teaching hospitals and private clinics located inRaichur and different taluks of Raichur district and reported by Polio Surveillance at DMHO with doorto door approach for all cases reported in the district of Raichur during the time period December 2011to November 2012 in the age group of 0-15 years.Results:Result of the 67 cases of AFP which were reported, 14 cases were found to be positive forNPEV, which shows a prevalence of 20.9% with male: female ratio of 1:1. The isolation of NPEVdecreases with the increase in age, cases associated with fever at the onset of NPEV associated AFPwere found to be 50%. The paralysis was found to be asymmetrical in 64% cases, the progression ofparalysis to peak within 4 days was found in 100% cases and there is no residual weakness found after60 days of paralysis onset. A clinical diagnosis of Guillian-Barre syndrome was found in 34.32% andNPEV 20.9%, transverse myelitis 5.97%, injection neuritis 1.49% and others 27.9%.Conclusion:The present study suggests that NPEV are dominant causes of AFP and different serotypesof NPEV are randomly distributed in North-Karnataka. The untypable isolates need furthercharacterization and analysis in order to determine their association with clinical presentation ofcases.
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