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Study of relationship between IL-1Ra gene polymorphism and GVHD in HLA – identical sibling allogenic transplants

Author(s): Ardeshir Ghavamzadeh | Maryam Sobhani | Pantea Izadi | Akbar Fotouhi | Kamran Ali Moghadam | Masoud Iravani, Mohammad Jahani | Babak Bahar | Asadollah Moosavi | Nima Hadiashar | Ardeshir Ghavamzadeh

Journal: Archives of Medical Science
ISSN 1734-1922

Volume: 3;
Issue: 1;
Start page: 52;
Date: 2007;
Original page

Keywords: BMT | cytokine | genotype

Introduction: The interleukin-1 (IL-1) gene family includes three members (IL-1a, IL-1b and IL-1Ra) that mediate immune and inflammatory responses. Interleukin-1 (IL-1) is an inflammatory cytokine involved in various autoimmune and inflammatory diseases. IL-1 receptor antagonist (IL-1Ra) is the naturally occurring antagonist to IL-1a and IL-1b. A variable number tandem repeat (VNTR) polymorphism in the IL-1Ra gene has been associated with increased IL-1Ra production and affects the severity of aGVHD. Material and methods: Three hundred and fifty pairs (175 HSCT recipients and their donors) were analyzed by VNTR/PCR. Because of haematological disorders all patients were transplanted. All genotypes were screened blind to the clinical outcome of the transplants. GVHD was graded using Glucksberg criteria. Results: The influence of different alleles on incidence of aGVHD was investigated with univariate analysis. None of them showed an association with aGVHD, but possession of allele 2 in donors was associated with less severe aGVHD, although the frequency of allele 2 in our study population was low. However, aGVHD correlated with recipient age, donor age and recipient disease, particularly thalassaemia. Conclusions: No significant correlation was observed between the IL-1Ra polymorphism and incidence of aGVHD. In addition there was a powerful association between diagnosis, particularly thalassaemia, and GVHD (26 out of 30 thalassaemia patients). These findings may help to predict the risk/severity of GVHD, which may contribute to selecting strategies for treatment/prevention in thalassaemia patients.
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