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Synthesis and Bioactivity of Benzothiazol Compounds Containing bisamide Unit

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Author(s): Wei Xue | Haichang Li | Huitao Fan | Zhuang Xiong | Yong He | Huixue Qi | Qiujuan Qiu

Journal: Scientific Journal of Frontier Chemical Development
ISSN 2167-163X

Volume: 2;
Issue: 2;
Start page: 43;
Date: 2012;
Original page

Keywords: Bisamide | Benzothiazol | Tobacco mosaic virus | Synthesis

ABSTRACT
Ten novel bisamide compounds containing benzothiazole unit were synthesized from the reactions of substituted benzoic acid and thionyl chloride, then coupled with substituted 2-aminobenzoic acid, cyclized in the existence of acetic anhydride, then coupled with substituted benzo[d]thiazol-2-amine.Their structures were characterized by 1H NMR, 13C NMR, IR and elemental analyses. Preliminary bioassay showed that some compounds exhibited anti-TMV activity at the concentration of 500 μg/mL.
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