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Synthesis and Biological Evaluation of a Highly Constrained Analogue of Methylthioadenosine (MTA)

Author(s): Gustavo Senra G. de Carvalho | Rafael Mafra de P. Dias | Jean-Louis Fourrey | Vânia L. Silva | Cláudio G. Diniz | Adilson D. da Silva

Journal: International Journal of Organic Chemistry
ISSN 2161-4687

Volume: 02;
Issue: 04;
Start page: 398;
Date: 2012;
Original page

Keywords: Synthesis | Biological Evaluation | Antibacterial | Analogue Methylthioadenosine

We describe the synthesis and the antibacterial evaluation 2’,N3-cyclonucleoside 3 analogue of MTA that is characterized by the presence of an additional linkage between the heterocyclic ring and the sugar moiety.
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