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Synthesis, Characterization and Biological activity of Zn (II) Schiff base complex against drug resistant pathogens

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Author(s): Saravanan Chandraleka*, Govindasamy Chandramohan, Subhasish Saha, Dharumadurai Dhanasekaran, Annamalai Panneerselvam

Journal: Drug Invention Today
ISSN 0975-7619

Volume: 2;
Issue: 1;
Start page: 8;
Date: 2010;
Original page

Keywords: Schiff bases | Zn (II) complex | Biological activity | multidrug resistant pathogens

ABSTRACT
The present study report the synthesis of the Zn(II) complex with Isonicotinic acid hydrazide and 2-acetylnaphthalene and their characterization using FTIR and Magnetic susceptibility studies. Our studies reveal the presence of different mode of linkages of the ligand with Zn(II). The IR spectra of the ligand imply that the ligand is bidentate with the amide group and azomethine –nitrogen as the two coordination sites was compared. The Zn(II) complex exhibit an identical pattern suggesting them to be isostructural with six coordinated spin free octahedral complex. The complex have been screened for their biological activity against the multidrug resistant bacterial and fungal pathogens. The results of this study show that the Zn (II) complex was effective against fungus than the bacteria.
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