Academic Journals Database
Disseminating quality controlled scientific knowledge

Synthesis of new heterocyclic compounds using 2-(4,7-dichloro-3,3-dimethyl-indolin-2-ylidene)malonaldehyde

ADD TO MY LIST
 
Author(s): Razieh Mohammadnejad Aghdam | Mehdi M. Baradaran | Arash Afghan

Journal: Current Chemistry Letters
ISSN 1927-7296

Volume: 2;
Issue: 1;
Start page: 13;
Date: 2013;
VIEW PDF   PDF DOWNLOAD PDF   Download PDF Original page

Keywords: Vilsmeier reagent | Malondialdehyde | Pyrazole | Pyrimidone | Thiopyrimidone

ABSTRACT
1-(2,5-Dichlorophenyl)hydrazine was converted via Fischer synthesis with isopropylmethylketone into 4,7-dichloro-2,3,3-trimethyl-3H-indole. Exposure of the indolenine to the vilsmeier reagent produced amino methylene malondialdehyde which reacted with hydrazine, arylhydrazine, urea, cyanoacetamide and thiourea to give pyrazols, pyrimidones and thiopyrimidone, respectively.

Tango Rapperswil
Tango Rapperswil

    
RPA Switzerland

Robotic Process Automation Switzerland