Author(s): Hanan Sekkak | El Mostapha Rakib | Medaghri-Alaoui Abdelouahid | Abderrafia Hafid | Abdelghani El Malki
Journal: International Journal of Organic Chemistry
ISSN 2161-4687
Volume: 03;
Issue: 01;
Start page: 37;
Date: 2013;
Original page
Keywords: Nitrile Imines | Cycloaddition | Pyrazoles | Cytotoxic Activity
ABSTRACT
N-Aryl-C-ethoxycarbonylnitrile imines (3a-g) react with ethyl cyanoacetate 1 in 1,3-dipolar cycloaddition to yield novel pyrazole-3,4-dicarboxylates (4a-g) in moderate yields. The reaction of pyrazole-3,4-dicarboxylates (4a, d) with hydrazine afforded pyrazolo[4,3-d]pyridazine-4,7-diones (5a, d) in good yields. All compounds were fully characterized by spectroscopic methods. Some of the newly synthesized compounds were evaluated for their cytotoxic activity against murine P815 mastocytoma cell line.
Journal: International Journal of Organic Chemistry
ISSN 2161-4687
Volume: 03;
Issue: 01;
Start page: 37;
Date: 2013;
Original page
Keywords: Nitrile Imines | Cycloaddition | Pyrazoles | Cytotoxic Activity
ABSTRACT
N-Aryl-C-ethoxycarbonylnitrile imines (3a-g) react with ethyl cyanoacetate 1 in 1,3-dipolar cycloaddition to yield novel pyrazole-3,4-dicarboxylates (4a-g) in moderate yields. The reaction of pyrazole-3,4-dicarboxylates (4a, d) with hydrazine afforded pyrazolo[4,3-d]pyridazine-4,7-diones (5a, d) in good yields. All compounds were fully characterized by spectroscopic methods. Some of the newly synthesized compounds were evaluated for their cytotoxic activity against murine P815 mastocytoma cell line.
