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Synthesis and in Vitro Cytotoxic Activity of Novel Pyrazole-3,4-dicarboxylates

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Author(s): Hanan Sekkak | El Mostapha Rakib | Medaghri-Alaoui Abdelouahid | Abderrafia Hafid | Abdelghani El Malki

Journal: International Journal of Organic Chemistry
ISSN 2161-4687

Volume: 03;
Issue: 01;
Start page: 37;
Date: 2013;
Original page

Keywords: Nitrile Imines | Cycloaddition | Pyrazoles | Cytotoxic Activity

ABSTRACT
N-Aryl-C-ethoxycarbonylnitrile imines (3a-g) react with ethyl cyanoacetate 1 in 1,3-dipolar cycloaddition to yield novel pyrazole-3,4-dicarboxylates (4a-g) in moderate yields. The reaction of pyrazole-3,4-dicarboxylates (4a, d) with hydrazine afforded pyrazolo[4,3-d]pyridazine-4,7-diones (5a, d) in good yields. All compounds were fully characterized by spectroscopic methods. Some of the newly synthesized compounds were evaluated for their cytotoxic activity against murine P815 mastocytoma cell line.
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