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Targeting the inflammation in HCV-associated hepatocellular carcinoma: a role in the prevention and treatment

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Author(s): Castello Giuseppe | Costantini Susan | Scala Stefania

Journal: Journal of Translational Medicine
ISSN 1479-5876

Volume: 8;
Issue: 1;
Start page: 109;
Date: 2010;
Original page

ABSTRACT
Abstract Epidemiological, preclinical and clinical studies demonstrated that chronic inflammation induced by hepatitis C virus (HCV) is crucial in hepatocellular carcinogenesis. The interaction between hepatocytes and microenvironment regards virus, inflammatory and immunocompetent cells, chemo- and cyto-kines, reactive oxygen species (ROS) and nitric oxide (NO), generating cell transformation. We suggest hepatocarcinoma (HCC) as a model in which the targeting of microenvironment determine neoplastic transformation. The present review focuses on: the role of inflammation in carcinogenesis, the clinical impact of HCC and the inadequacy of the actual therapy, the chemoprevention targeting the microenvironment.
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