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The Three Catecholics Benserazide, Catechol and Pyrogallol are GPR35 Agonists

Author(s): Huayun Deng | Ye Fang

Journal: Pharmaceuticals
ISSN 1424-8247

Volume: 6;
Issue: 4;
Start page: 500;
Date: 2013;
Original page

Keywords: GPR35 | benserazide | catechol | pyrogallol

Nearly 1% of all clinically used drugs are catecholics, a family of catechol-containing compounds. Using label-free dynamic mass redistribution and Tango β-arrestin translocation assays, we show that several catecholics, including benserazide, catechol, 3-methoxycatechol, pyrogallol, (+)-taxifolin and fenoldopam, display agonistic activity against GPR35.
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