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Tobacco Smoking and Lung Cancer; Perception-changing facts

Author(s): Muhammad Furrukh

Journal: Sultan Qaboos University Medical Journal : SQUMJ
ISSN 2075-051X

Volume: 13;
Issue: 3;
Start page: 345;
Date: 2013;
Original page

Keywords: Tobacco Smoking | Lung Neoplasms | Nicotine | EML4 ALK fusion protein | human | K-Ras Gene | Receptor | Epidermal Growth Factor | Carcinogens.

Tobacco smoking remains the most established cause of lung carcinogenesis and other disease processes. Over the last 50 years, tobacco refinement and the introduction of filters have brought a change in histology, and now adenocarcinoma has become the most prevalent subtype. Over the last decade, smoking also has emerged as a strong prognostic and predictive patient characteristic along with other variables. Thisarticle briefly reviews scientific facts about tobacco, and the process and molecular pathways involved in lung carcinogenesis in smokers and never-smokers. The evidence from randomised trials about tobacco smoking’s impact on lung cancer outcomes is also reviewed.
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