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TOXICITY OF Ipomoea alba L. (CONVOLVULACEAE)

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Author(s): Guilherme Emerson Barrella | Riad Naim Younes | Antonio Drauzio Varella | Edna Frasson de Souza Montero | Mateus Luís Barradas Paciencia | Ingrit Elida Collantes Díaz | Maria Martha Bernardi | Suzana Peres Pimentel | vana Barbosa Suffredini

Journal: Pharmacologyonline
ISSN 1827-8620

Volume: 3;
Issue: 3;
Start page: 39;
Date: 2012;
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Keywords: Ipomoea alba | drug toxicity | general activity | central nervous system | autonomous system

ABSTRACT
Objective: To evaluate the influence of plant extract (EB1493) obtained from Ipomoea alba, Convolvulaceae over general activity and over toxicity of central nervous system, autonomous nervous system, sensorial and psychomotor systems in mice and in rats.Methods: Acute toxicity assay was done with animals that received different doses of EB1493, intraperitonealy. For each dose, more than 25 parameters related to central and autonomous nervous systems, sensorial and psychomotor systems were evaluated, as well as LD50 was determined A multi-dose assay (MDTA)was also performed, in which the animals topically received EB1493 three times/day in the mouth mucosa, for 11 days, and were evaluated for the same parameters considered in the first assay at day 1, day 2, day 5 and day 11. Results: LD50 is 2.19 g/kg, considered harmful. General activity, touch response, tail squeeze, hindquarterfall, body tone and grip reflex were significantly altered after administration of both higher doses in the first stage of the experiment, as well as ptosis, auricular and corneal reflexes and defecation were altered in the second stage of the experiment. Alterations in general activity, touch response, piloerection, micturition and defecation were observed in MDTA, in some sessions. Differences in body weigh were observed as well. Conclusions: The first findings related to the toxicity profile of EB1493 were optimistic for have shown low toxicity. Further pharmacological, chemical and toxicological analyses are going to be made, in order togather additional information on EB1493 antimicrobial potential.
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