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Toxicogenomics and cancer pathogenesis

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Author(s): Gupta N. | Gupta G. | Trivedi S. | Patil P. | Gupta M. | Jhadav A. | Vamsi K.K. | Khairnar Y. | Boraste A. | Mujapara A.K. | Joshi B.

Journal: International Journal of Genetics
ISSN 0975-2862

Volume: 1;
Issue: 2;
Start page: 47;
Date: 2009;
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ABSTRACT
Toxicogenomics is emerging field give idea of the application of large-scale differential geneexpression data to toxicology, starting to influence drug discovery and development in the pharmaceuticalindustry. Its future potential in cancer pathogenesis, study of poisons and poisoning and has an ancient andvenerable history. Toxicogenomics is the merging of toxicology with technologies that have been developed,together with bioinformatics, to identify and quantify global gene expression changes for gene therapy.Immunotoxic processes and the development of in vitro screening assays is therefore expected to be ofvalue for mechanistic insight into immunotoxicity and hazard identification of existing and novel compounds.Successful application of toxicogenomic approaches, such as DNA microarrays, inextricably relies onappropriate data management, the ability to extract knowledge from massive amounts of data and theavailability of functional information for data interpretation. Toxicogenomics is considered a valuable tool forreducing pharmaceutical candidate attrition by facilitating earlier identification, prediction and understandingof toxicities. Pharmaco-epidemiological (toxicogenomics) data is now available for both antiepileptic drugs,evidence for human carcinogenicity. Therapeutic researches converge triad of rejuvenation, regeneration orreplacement strategies that rely on self-healing processes, stem cell regeneration organ transplantation.Metastases studies usually display more genetic changes than the primary tumour. Helix-loop-helixapplication in translational and functional toxicogenomics transcription factors has been implicated indiverse cellular processes such as proliferation, apoptosis, differentiation, and migration.
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