Author(s): Bruno Mégarbane
Journal: Open Access Emergency Medicine
ISSN 1179-1500
Volume: 2010;
Issue: default;
Start page: 67;
Date: 2010;
Original page
ABSTRACT
Bruno MégarbaneRéanimation Médicale et Toxicologique, Hôpital Lariboisière and Université Paris-Diderot, Paris, FranceAbstract: Ethylene glycol (EG) and methanol are responsible for life-threatening poisonings. Fomepizole, a potent alcohol dehydrogenase (ADH) inhibitor, is an efficient and safe antidote that prevents or reduces toxic EG and methanol metabolism. Although no study has compared its efficacy with ethanol, fomepizole is recommended as a first-line antidote. Treatment should be started as soon as possible, based on history and initial findings including anion gap metabolic acidosis, while awaiting measurement of alcohol concentration. Administration is easy (15 mg/kg-loading dose, either intravenously or orally, independent of alcohol concentration, followed by intermittent 10 mg/kg-doses every 12 hours until alcohol concentrations are
Journal: Open Access Emergency Medicine
ISSN 1179-1500
Volume: 2010;
Issue: default;
Start page: 67;
Date: 2010;
Original page
ABSTRACT
Bruno MégarbaneRéanimation Médicale et Toxicologique, Hôpital Lariboisière and Université Paris-Diderot, Paris, FranceAbstract: Ethylene glycol (EG) and methanol are responsible for life-threatening poisonings. Fomepizole, a potent alcohol dehydrogenase (ADH) inhibitor, is an efficient and safe antidote that prevents or reduces toxic EG and methanol metabolism. Although no study has compared its efficacy with ethanol, fomepizole is recommended as a first-line antidote. Treatment should be started as soon as possible, based on history and initial findings including anion gap metabolic acidosis, while awaiting measurement of alcohol concentration. Administration is easy (15 mg/kg-loading dose, either intravenously or orally, independent of alcohol concentration, followed by intermittent 10 mg/kg-doses every 12 hours until alcohol concentrations are
