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Ultrasonics Promoted Synthesis of 5-(Pyrazol-4-yl)-4,5-Dihydropyrazoles Derivatives

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Author(s): Jorge Trilleras | Efraín Polo | Jairo Quiroga | Justo Cobo | Manuel Nogueras

Journal: Applied Sciences
ISSN 2076-3417

Volume: 3;
Issue: 2;
Start page: 457;
Date: 2013;
Original page

Keywords: pyrazolines | cyclocondensation | sonication | chalcones | hydrazines

ABSTRACT
A series of new 1,3-diaryl-5-(1-phenyl-3-methyl-5-chloropyrazol-4-yl)-4,5-dihydropyrazole derivatives have been synthesized under sonication conditions in ethanol or methanol/glacial acetic acid mixture (5/1 ratio) with two equivalents of hydrazines and seven kinds of chalcone-like heteroanalogues obtained from 5-chloro-3-methyl-1-phenyl-1H-pyrazole-4-carbaldehyde. The structures were established on the basis of NMR, IR, MS and element analysis. This method provides several advantages over current reaction methodologies, including a simple work-up procedure, shorter reaction times (2–20 min) and good yields (65%–80%).
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