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Unique Variant Complex Chromosome Translocation in Myeloid Leukemia: Report of a Case and Literature Review

Author(s): Abolfazl Movafagh | Mehrdad Hashemi | Mojtaba Ghadiani | Reza Mirfakhraei | Hossein Darvish | Davood Zare Abdollahi | Hamid Ghaedi | Shamsi Safari | Leyla HaghNejad | Sara Mosammami | Niloofar Safavi Naeini | Ramin Miri | Mostafa Rezaei Tavirani

Journal: Middle East Journal of Cancer
ISSN 2008-6709

Volume: 3;
Issue: 2 ;
Start page: 85;
Date: 2012;
Original page

Keywords: Complex | Chromosome | Translocation | CML | Leukemia

Background: According to the literature, there are a number of chronic and acute myeloid leukemias with unique, complex chromosome translocations. This study aims to conduct a brief review of the incidence of complex chromosome translocations in myeloid leukemia and reports a case of myeloid leukemia with complex chromosome translocations.Methods: We conducted a web-based search for all peer review articles published on the subject of complex chromosome tranlsocations in chronic and acute myeloid leukemia in MEDLINE, PubMed and Mitelman ( databases in addition to other pertinent web references. In addition, we performed conventional cytogenetic studies of 24- to 72-h cultures on bonemarrow/peripheral blood cells obtained from the current case. Cells were finally treated by the giemsa-trypsin-giemsa banding technique.Results: The result of this case revealed an abnormal karyotype that had a novel complex translocation which involved chromosomes 2, 5, 9, and 22. We performed karyotyping after the initiation of chemotherapy. Karyotyping results showed a complex karyotype 46,XX,t(9;22;2;5).Conclusion: This study discusses a case of chronic myeloid leukemia with complex chromosome translocations and may provide novel information regarding these translocations in leukemias.

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