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Use of a naturally occurring codon bias for identifying topoisomerase mutations in ciprofloxacin resistant Escherichia coli using PCR and future prospects with other bacterial genera: A pilot study

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Author(s): Subramanian Krishnan | Dheepikaa Balasubramanian | B. Appala Raju | Baddireddi Subadhra Lakshmi

Journal: Advances in Biological Chemistry
ISSN 2162-2183

Volume: 02;
Issue: 04;
Start page: 366;
Date: 2012;
Original page

Keywords: Escherichia coli Gyrase A | Codon Bias | Mutation | Ciprofloxacin Resistance | PCR

ABSTRACT
We developed a novel PCR method aimed at identi- fying and amplifying native codon sequences of muta- tion-prone amino acids in DNA gyrase implicated in quinolone resistance using a naturally occurring co- don bias in E. coli DNA gyrase A.
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