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VARIATION IN THE YAK CALPASTATIN GENE (CAST)

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Author(s): Yang G., Zhou H., Hu J., Luo Y. and Hickford J.G.H.

Journal: International Journal of Genetics
ISSN 0975-2862

Volume: 4;
Issue: 1;
Start page: 72;
Date: 2012;
Original page

Keywords: CAST | genetic variation | Yak (Bos grennies) | PCR- single strand conformational polymorphism (PCR-SSCP).

ABSTRACT
Calpastatin (CAST) is a specific inhibitor of calpain (calcium-dependent cysteine protease). This study investigated the potential for variation in yak (Bos grennies) CAST. PCR-SSCP analysis of exon 6 of yak CAST revealed three unique patterns (named A-C). Sequencing of the amplicons revealed two nucleotide substitutions. One substitution (c.398G/C) would nominally change the amino acid sequence (p.S133T) of yak calpastatin. The variant sequence A which carried c.398C was the most common in the yaks tested (95.1%). This is the first report that found yak CAST is variable, and as in pigs, sheep and cattle, this variation may affect animal production traits.
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