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Vitex agnus-castus essential oil affects thyroid C cells and bone metabolism in middle-aged male rats

Author(s): Pantelić Jasmina | Filipović B. | Šošić-Jurjević Branka | Ajdžanović V. | Trifunović Svetlana | Medigović Ivana | Milošević Verica

Journal: Acta Veterinaria
ISSN 0567-8315

Volume: 63;
Issue: 1;
Start page: 23;
Date: 2013;
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Keywords: bone | essential oil | thyroid C cells | Vitex agnus-castus

Ageing in men is accompanied by an increased occurrence of osteoporosis, but traditional hormonal replacement therapy elevates the risk of developing endocrine cancer. Vitex agnus-castus L. (Vac) essential oil is commonly used as an alternative therapy for ageing symptoms in both men and women. It is known that calcitonin (CT), thyroid C cell hormone, inhibits bone resorption. The purpose of this experimental study was to investigate the influence of Vac essential oil administration on the immunohistomorphometric features of thyroid C cells and bone metabolism in 16-month-old male Wistar rats. The first group of animals (n=8) was treated subcutaneously (s.c.) with 60 mg/kg of Vac essential oil once a day for 3 weeks. Control animals (n=8) received sterile olive oil s.c. by the same schedule. After Vac treatment significant increases (p
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